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Cirrhosis Content Supplied by NHS Choices
Introduction

Cirrhosis is scarring of the liver caused by continuous long-term liver damage. Scar tissue replaces healthy tissue in the liver and prevents the liver working properly.

The damage caused by cirrhosis can't be reversed and can eventually become so extensive that your liver stops functioning. This is called liver failure.

Cirrhosis can be fatal if the liver fails. However, it usually takes years for the condition to reach this stage and treatment can help slow its progression.

Each year around 4,000 people in the UK die from cirrhosis, and 700 people with the condition need a liver transplant to survive.

Signs and symptoms

There are usually few symptoms in the early stages of cirrhosis. However, as your liver loses its ability to function properly, you're likely to experience a loss of appetite, nausea and itchy skin.

Symptoms in the later stages can include jaundice, vomiting blood, dark, tarry-looking stools, and a build-up of fluid in the legs (oedema) and abdomen (ascites).

Read more about the symptoms of cirrhosis.

When to see your GP

As cirrhosis doesn't have many obvious symptoms in the early stages, it's often picked up during tests for an unrelated illness.

See your GP if you have any of the following symptoms:

  • fever and shivering
  • shortness of breath
  • vomiting blood
  • very dark or black, tarry stools (faeces)
  • periods of confusion or drowsiness

Read more about diagnosing cirrhosis.

What causes cirrhosis

In the UK, the most common causes of cirrhosis are:

  • drinking too much alcohol (alcohol misuse) over many years
  • being infected with the hepatitis C virus for a long time
  • a condition called non-alcoholic steatohepatitis (NASH), which causes excess fat to build up in the liver

NASH is on the rise in the UK as a result of increasing levels of obesity and reduced physical activity. It's likely it will overtake alcohol and hepatitis C as the most common cause of cirrhosis.

Less common causes of cirrhosis include hepatitis B infection and inherited liver diseases, such as haemochromatosis.

Read more about the causes of cirrhosis.

Treating cirrhosis

There's currently no cure for cirrhosis. However, it's possible to manage the symptoms and any complications, and slow its progression.

Treating underlying conditions that may be the cause, such as using anti-viral medication to treat a hepatitis C infection, can also stop cirrhosis getting worse.

You may be advised to cut down on or stop drinking alcohol, or lose weight if you're overweight. A wide range of alcohol support services are available.

In its more advanced stages, the scarring caused by cirrhosis can make your liver stop functioning. In this case, a liver transplant is the only treatment option.

Read more about treating cirrhosis.

Preventing cirrhosis

Not exceeding the recommended limits for alcohol consumption is the best way of preventing alcohol-related cirrhosis.

It's advised that:

  • men and women do not regularly drink more than 14 units a week
  • you spread your drinking over three days or more if you drink as much as 14 units a week

Read more about alcohol units.

Hepatitis B and C are infections you can get by having unprotected sex or sharing needles to inject drugs.

Using a condom during sex and not injecting drugs will reduce your risk of developing hepatitis B and C.

A vaccine for hepatitis B is available, but there's currently no vaccine for hepatitis C.

Read more about preventing cirrhosis.

Symptoms of cirrhosis

There are usually few symptoms during the early stages of cirrhosis. Noticeable problems tend to develop as the liver becomes more damaged.

In early-stage cirrhosis, the liver is able to function properly despite being damaged. As the condition progresses, symptoms tend to develop when liver functions are affected.

Symptoms of cirrhosis can include:

  • tiredness and weakness
  • loss of appetite
  • weight loss and muscle wasting
  • feeling sick (nausea) and vomiting
  • tenderness or pain around the liver area
  • tiny red lines (blood capillaries) on the skin above waist level
  • very itchy skin
  • yellowing of the skin and the whites of the eyes (jaundice)
  • a tendency to bleed and bruise more easily, such as frequent nosebleeds or bleeding gums
  • hair loss
  • fever and shivering attacks
  • swelling in the legs, ankles and feet caused by a build-up of fluid (oedema)
  • swelling in your tummy (abdomen) caused by a build-up of fluid known as ascites - severe cases can make you look heavily pregnant

You may also notice changes in your personality, problems sleeping (insomnia), memory loss, confusion and difficulty concentrating.

This is known as encephalopathy, and occurs when toxins affect your brain because your liver is unable to remove them from your body.

Late-stage symptoms

In the later stages of cirrhosis, you may vomit blood or have tarry, black stools.

This is because blood can't flow through the liver properly, which causes an increase in blood pressure in the vein that carries blood from the gut to the liver (portal vein).

The increase in blood pressure forces blood through smaller, fragile vessels that line your stomach and gullet (varices).

These can burst under high blood pressure, leading to internal bleeding, which is visible in vomit and your stools.

Over time, the toxins that would normally be removed from the body by a healthy liver can cause multiple organ failure, followed by death.

When to seek medical help

You should see your GP if you have persistent signs and symptoms of cirrhosis.

Seek immediate medical help if you develop the following symptoms, particularly if you've previously been diagnosed with cirrhosis:

Causes of cirrhosis

There are many different causes of cirrhosis. In the UK, the most common causes are drinking excessive amounts of alcohol and long-term hepatitis C infections.

In some cases, no specific cause is identified.

Alcohol consumption

The liver breaks down poisons (toxins), such as alcohol, but too much alcohol can scar and damage the liver's cells.

Men and women who drink more than 14 units of alcohol a week are considered to be drinking too much.

If you're a heavy drinker, your chances of developing cirrhosis are increased.

But cirrhosis of the liver isn't just a condition that affects people dependent on alcohol. You can also develop cirrhosis if you're a heavy social drinker.

Alcohol-related cirrhosis usually develops after 10 or more years of heavy drinking. For unknown reasons, some people are more susceptible to liver cell damage than others.

Women who drink heavily are more susceptible to liver damage than men, partly because of their different body size and build.

Stages of alcoholic liver damage

People who drink excessively and continue to drink heavily develop cirrhosis in three separate stages:

  • first stage - known as "fatty liver", which almost all excessive drinkers develop, it's a side effect of the liver breaking alcohol down and disappears when you drink less
  • second stage - around 20-30% of people who continue to drink heavily develop alcoholic hepatitis; the liver becomes inflamed during this stage, and it can lead to death if it deteriorates into its most extreme form, liver failure
  • third stage - cirrhosis, which about 10% of heavy drinkers develop

This risk of developing cirrhosis, along with the risk of alcoholic hepatitis, is one of the main reasons the government recommends that men and women should not regularly drink more than 14 units a week.

If you do drink as much as 14 units a week, it's advised that you spread your drinking over three or more days.

A unit of alcohol is roughly equivalent to half a pint of normal-strength lager or a single measure (25ml) of spirits. A small glass of wine (125ml) is about 1.5 units.

Read more about alcohol units.

Your GP can give you help and advice if you're finding it difficult to cut down on the amount you drink.

Hepatitis

Hepatitis is inflammation of the liver. Left untreated, it can damage the liver over many years, eventually resulting in cirrhosis.

In the UK, hepatitis C is the most common form of hepatitis. The hepatitis C virus is usually transmitted through blood-to-blood contact, most commonly by sharing needles used to inject drugs.

Two other types of hepatitis infection, hepatitis B and D, can also cause cirrhosis.

Non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH) is a severe liver condition that can lead to cirrhosis.

As with alcohol-related liver disease, the early stage of NASH is the build-up of excess fat in the liver. This fat is associated with inflammation and scarring, which could lead to cirrhosis.

NASH can develop in people who are obese or have diabetes, high levels of fat in the blood (high cholesterol) and high blood pressure.

Most people with NASH feel well and aren't aware they have a problem until cirrhosis occurs and liver function is affected.

NASH is on the rise in the UK as a result of increasing levels of obesity and reduced physical activity. It's likely it will overtake alcohol and hepatitis C as the most common cause of cirrhosis.

Other causes

There are a number of other conditions that can prevent the liver functioning healthily and lead to cirrhosis.

These include:

  • autoimmune liver disease - the immune system usually makes antibodies to attack bacteria and viruses, but if you have an autoimmune disease, such as autoimmune hepatitis, primary biliary cirrhosis or primary sclerosing cholangitis (PSC), your immune system will make antibodies that attack healthy organs
  • some rare genetic conditions - such as haemochromatosis (a build-up of iron in the liver and other parts of the body) and Wilson's disease (a build-up of copper in the liver and other parts of the body)
  • any condition that causes the bile ducts to become blocked - such as cancer of the bile ducts or pancreatic cancer
  • Budd-Chiari syndrome - caused by blood clots blocking the veins that carry blood from the liver

Less commonly, the use of certain medications, such as amiodarone and methotrexate, can also cause cirrhosis.

Diagnosing cirrhosis

If your GP suspects cirrhosis, they'll check your medical history and carry out a physical examination to look for signs of chronic liver disease.

If your GP suspects your liver is damaged, you'll be referred for tests to confirm the diagnosis.

Tests

You may have a number of different tests, including those described below.

Blood tests

Blood tests can measure your liver function and the amount of liver damage.

A blood test may be used to measure the levels of the liver enzymes alanine transaminase (ALT) and aspartate transferase (AST) in your blood, as these will be raised if you have inflammation of the liver (hepatitis).

Scans

An ultrasound scan, transient elastography scan, computerised tomography (CT) scan or a magnetic resonance imaging (MRI) scan may be carried out on your liver.

A transient elastography scan is similar to an ultrasound scan carried out during pregnancy and is sometimes known as a Fibroscan.

These scans can produce detailed images of your liver or check liver stiffness to identify any scarring.

The Lab Tests Online UK website has more information about ALT and AST measurements.

Liver biopsy

A liver biopsy is where a fine needle is inserted into your body, usually between your ribs, to remove a small sample of liver cells. The sample is sent to a laboratory so it can be examined under a microscope.

The biopsy is usually carried out under local anaesthetic, either as a day case or with an overnight stay in hospital.

The outcome of the biopsy will confirm a diagnosis of cirrhosis and may provide more information about the cause.

Transient elastography is increasingly being used as an alternative to a biopsy in the diagnosis of cirrhosis.

Endoscopy

An endoscopy is where a thin, long, flexible tube with a light and video camera at the end called an endoscope is passed down your throat and into your stomach.

Images of your oesophagus, the tube from your throat to your stomach, and your stomach are transmitted to an external screen, where any swollen vessels (varices), which are a sign of cirrhosis, can be seen.

Grading

There are several different grading systems for cirrhosis according to how serious it is.

One system is the Child-Pugh score, which, based on your examination and laboratory tests, grades cirrhosis from A (relatively mild) to C (severe).

An alternative system called model of end-stage liver disease (MELD) uses the results of a blood test to help identify people who need an urgent liver transplant.

Treating cirrhosis

Cirrhosis can't be cured, so treatment aims to manage the symptoms and any complications, and stop the condition getting worse.

It's usually not possible to reverse liver damage that's already occurred, although recent research suggests this may eventually be possible in cases where the underlying cause can be successfully treated.

Treatment is likely to take place at a hospital with a specialist hepatology unit, which treats disorders of the liver, gallbladder and biliary ducts.

Stopping cirrhosis getting worse

Taking medication to treat the underlying cause of the liver damage and making healthy lifestyle changes can help stop cirrhosis getting worse and reduce your risk of developing further health problems.

Medication

The medication you need will depend on the specific cause of the damage to your liver.

For example, if you have viral hepatitis, you may be prescribed anti-viral medications.

If you have autoimmune hepatitis, you may be given steroid medication (corticosteroids) or medication to suppress your immune system (immunosuppressants).

Lifestyle changes

There are a number of things you can do to help yourself stay healthy and reduce your chances of developing further problems if you have cirrhosis.

These include:

  • completely avoiding alcohol, regardless of the cause of your cirrhosis, as alcohol consumption increases the rate at which the condition progresses
  • losing weight if you're overweight or obese
  • regular exercise to reduce muscle wasting
  • practising good hygiene to reduce your chances of developing infections
  • speaking to your GP about vaccinations you may need, such as the annual flu vaccine or travel vaccines
  • speaking to your GP or pharmacist if you're taking over-the-counter or prescription medications, as cirrhosis can affect the way your body processes some medicines

Malnutrition is common in people with cirrhosis, so it's important to ensure you have a balanced diet to help you get all the nutrients you need.

Avoiding salty foods and not adding salt to foods you eat can help reduce your risk of developing swelling in your legs, feet and tummy (abdomen) caused by a build-up of fluid.

See tips for a lower salt diet for more information.

The damage to your liver can also mean it's unable to store glycogen, a carbohydrate that provides short-term energy.

When this happens, the body uses its own muscle tissue to provide energy between meals, which leads to muscle wasting and weakness. This means you may need extra calories and protein in your diet.

Healthy snacking between meals can top up your calories and protein. It may also be helpful to eat three or four small meals a day, rather than one or two large meals.

Easing symptoms

A number of treatments can ease the symptoms of cirrhosis, including:

  • a low-salt diet or tablets called diuretics to reduce the amount of fluid in your body
  • tablets to reduce high blood pressure in your portal vein, the main vein that transports blood from the gut to the liver, and prevent or treat any infection
  • creams to reduce itching

Managing complications

In cases of advanced cirrhosis, complications caused by the condition may need treatment.

Swollen varices

If you vomit blood or pass blood in your stools, you probably have swollen veins in your oesophagus, the long tube that carries food from the throat to the stomach. These are known as oesophageal varices.

Urgent medical attention is required in these cases. This means seeing your GP or going to the accident and emergency (A&E) department of your nearest hospital immediately.

Certain procedures can help stop the bleeding and reduce the risk of it happening again, such as:

  • banding - a procedure where a thin, flexible tube is passed down your throat (endoscopy) is carried out, and a small band is placed around the base of the varices to help control the bleeding
  • injection glue therapy - after an endoscopy, a type of medical "super glue" is injected into the varices to make the blood clot, which helps stop the bleeding
  • Sengstaken tube with a balloon on the end - a special tube is passed down your throat into your stomach and the balloon is inflated, which puts pressure on the varices and helps stop the bleeding; you'll be heavily sedated during the procedure
  • transjugular intrahepatic portosystemic stent shunt (TIPSS) - a metal tube called a stent is passed across your liver to join two large veins called the portal vein and hepatic vein; this creates a new route for your blood to flow through, relieving the pressure that causes the varices

You may also be given a type of medication called a beta-blocker, such as propanolol, to reduce the risk of bleeding or the severity of any bleed that does occur.

Fluid in the tummy and legs

A build-up of fluid around your stomach area (ascites) and fluid around your legs and ankles (peripheral oedema) are common complications of advanced cirrhosis. They'll need to be addressed as soon as possible.

You may have 20 to 30 litres of free water in your stomach area, which can make it difficult for you to eat and breathe properly.

The main treatments for ascites and oedema are restricting salt in your diet and taking diuretic tablets, such as spironolactone or furosemide.

If the fluid around your stomach becomes infected, you may need to be treated with antibiotics. Alternatively, antibiotics may be used on a regular basis to prevent infection in people at high risk.

In severe cases of ascites, tubes may be used to drain the fluid from your abdomen. This will usually be repeated every few weeks.

Encephalopathy

People with cirrhosis can sometimes develop problems with their brain function (encephalopathy). This occurs because the liver isn't clearing toxins properly.

The main treatment for encephalopathy is lactulose syrup. This acts as a laxative to help clear the bowels, and helps the body remove the toxins that build up in the body when the liver is failing. In some cases, other laxatives or an enema may be used.

Bleeding

Cirrhosis can affect the liver's ability to make the blood clot, leaving you at risk of severe bleeding if you cut yourself.

Vitamin K and a blood product called plasma can be given in emergencies to treat episodes of bleeding. You'll need to apply pressure to any cuts that bleed.

You should seek specialist advice before having medical procedures, including any dental work.

Liver transplant

Your liver may stop functioning if it's severely damaged by scarring. In this situation, a liver transplant is the only option.

This is a major procedure that involves removing your diseased liver and replacing it with a healthy donor liver.

You will probably have to wait a long time for a liver transplant as there are more people waiting for a transplant than there are donors.

The NHS Blood and Transplant Organ Donation website has more information about transplants and joining the Organ Donor Register.

Preventing cirrhosis

You can reduce your chances of developing cirrhosis by limiting your alcohol consumption and protecting yourself from a hepatitis infection.

Limiting your alcohol consumption

Heavy alcohol consumption is one of the most common causes of liver cirrhosis. One of the best ways to avoid this is to keep within recommended limits:

  • men and women are advised not to regularly drink more than 14 units a week
  • spread your drinking over three days or more if you drink as much as 14 units a week

If you have cirrhosis, you should stop drinking alcohol immediately - it speeds up the rate at which the condition progresses, regardless of the cause.

Read more about alcohol misuse.

Protect yourself from hepatitis

Cirrhosis can be caused by infectious conditions, such as hepatitis B and C. Hepatitis B and C can be caught through having unprotected sex or by sharing needles to inject drugs.

Using a condom when having sex will help you avoid the risk of getting hepatitis, as will avoiding injecting drugs.

Anyone who's at risk of getting hepatitis B, such as police officers and social care workers, can be protected by being vaccinated against the condition. There's currently no vaccine for hepatitis C.

People born in areas of the world where hepatitis B and C are widespread, such as parts of south Asia and Africa, need to be screened for hepatitis as early treatment can help prevent the onset of cirrhosis.

"I haven't touched a drop for three years now"

Six months of heavy drinking during a stressful period at work left Judith Heath with cirrhosis. She tells her story.

"I used to work as a practice manager for two GPs and found my job very stressful. I had problems with one of the doctors and became very stressed and anxious about going into work.

"I'd come home at night really wound up. It became a running joke that my husband would greet me at the door with a glass of wine. I drank heavily for six months, getting through a bottle-and-a-half of wine a night.

"Even though I didn't know it then, I already had symptoms of liver failure. Towards the end of that six-month period I had swollen ankles, but just thought it was because I was on my feet all day.

"I was also being sick every day, but again I put that down to nerves and anxiety about work. I wasn't eating much and didn't feel hungry, but I carried on drinking every night.

"Eventually, my employer said he could smell alcohol on my breath. I was suspended for being drunk at work. He also said I had yellow eyes, so I went to see my own GP. He took one look at me and said, "I think you've got a liver problem because you're so jaundiced."

"They did some blood tests and found that I was very ill. I was rushed into hospital, which was really traumatic. I suddenly filled up with fluid in my arms, legs and midriff, and my blood wasn't clotting, which really worried them.

"They told my husband that my liver wasn't functioning and they didn't know whether I would live or die. Finally, after six days on a drip, they said I was responding to the treatment, which had reduced the fluid in my body and brain.

"They did an ultrasound scan which showed that my liver was badly damaged and I had cirrhosis. I stayed in hospital for a month on diuretic tablets and a zero-fat, zero-salt diet, with no more than a half-pint of fluid a day.

"When I came home I'd lost three stone and looked like a skeleton, very gaunt and drawn. I had to stay on the restricted diet for 18 months and keep taking the diuretic tablets. I eventually started drinking soya milk to get some protein, and my weight went back up.

"I stopped drinking alcohol completely and haven't touched a drop for three years now. Doctors thought I would need a liver transplant but, remarkably, it has regenerated and functions really well now.

"I have some nerve damage in my feet, called peripheral neuropathy, but apart from that I'm really well. My hair, nails and skin were in terrible shape, but they're all in great condition now.

"I would advise anyone who thinks they're drinking too much and feels unwell to visit their GP immediately, to help cut down the drinking and get blood tests for your liver.

"My experience shows that your liver can deteriorate really fast - and there are very few early symptoms, so you could be really ill and not even know it."


 
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